diff --git a/CHANGES b/CHANGES
index dab96a8f17..562164c945 100644
--- a/CHANGES
+++ b/CHANGES
@@ -1,3 +1,6 @@
+4828.	[bug]		Do not use thread-local storage for storing LMDB reader
+			locktable slots. [RT #46556]
+
 4827.	[misc]		Add a precommit check script util/checklibs.sh
 			[RT #46215]
 
diff --git a/bin/named/server.c b/bin/named/server.c
index 14f6bcfebe..69a52693bd 100644
--- a/bin/named/server.c
+++ b/bin/named/server.c
@@ -12085,8 +12085,13 @@ nzd_env_reopen(dns_view_t *view) {
 		}
 	}
 
+	/*
+	 * MDB_NOTLS is used to prevent problems after configuration is
+	 * reloaded, due to the way LMDB's use of thread-local storage (TLS)
+	 * interacts with the BIND9 thread model.
+	 */
 	status = mdb_env_open(env, view->new_zone_db,
-			      MDB_NOSUBDIR|MDB_CREATE, 0600);
+			      MDB_NOSUBDIR|MDB_NOTLS|MDB_CREATE, 0600);
 	if (status != 0) {
 		isc_log_write(dns_lctx, DNS_LOGCATEGORY_GENERAL,
 			      ISC_LOGMODULE_OTHER, ISC_LOG_ERROR,
diff --git a/lib/dns/view.c b/lib/dns/view.c
index 87420066a6..df5d8f4b66 100644
--- a/lib/dns/view.c
+++ b/lib/dns/view.c
@@ -2122,8 +2122,13 @@ dns_view_setnewzones(dns_view_t *view, isc_boolean_t allow, void *cfgctx,
 		}
 	}
 
+	/*
+	 * MDB_NOTLS is used to prevent problems after configuration is
+	 * reloaded, due to the way LMDB's use of thread-local storage (TLS)
+	 * interacts with the BIND9 thread model.
+	 */
 	status = mdb_env_open(env, view->new_zone_db,
-			      MDB_NOSUBDIR|MDB_CREATE, 0600);
+			      MDB_NOSUBDIR|MDB_NOTLS|MDB_CREATE, 0600);
 	if (status != 0) {
 		isc_log_write(dns_lctx, DNS_LOGCATEGORY_GENERAL,
 			      ISC_LOGMODULE_OTHER, ISC_LOG_ERROR,