diff --git a/configure.ac b/configure.ac
index 035a7d0cff..4e6220d499 100644
--- a/configure.ac
+++ b/configure.ac
@@ -552,9 +552,15 @@ PKG_CHECK_MODULES([LIBUV], [libuv >= 1.0.0], [],
 		  [AC_MSG_ERROR([libuv not found])])
 
 # libuv recvmmsg support
-AC_CHECK_DECLS([UV_UDP_RECVMMSG, UV_UDP_MMSG_FREE, UV_UDP_MMSG_CHUNK], [], [], [[#include <uv.h>]])
-AS_CASE([$host],
-	[*-musl],[AC_DEFINE([HAVE_DECL_UV_UDP_RECVMMSG], [0], [Disable recvmmsg support on systems with MUSL glibc])])
+AC_CHECK_DECLS([UV_UDP_MMSG_FREE, UV_UDP_MMSG_CHUNK], [], [], [[#include <uv.h>]])
+AC_MSG_CHECKING([whether struct msghdr uses padding for alignment])
+AC_COMPILE_IFELSE([AC_LANG_PROGRAM([#include <sys/socket.h>],
+				   [const struct msghdr h = { .__pad1 = 0, .__pad2 = 0 };])],
+		  [AC_MSG_RESULT([yes])
+		   AC_DEFINE([HAVE_DECL_UV_UDP_RECVMMSG],
+			     [0], [Disable recvmmsg support on systems with MUSL glibc])],
+		  [AC_MSG_RESULT([no])
+		   AC_CHECK_DECLS([UV_UDP_RECVMMSG], [], [], [[#include <uv.h>]])])
 
 # [pairwise: --enable-doh --with-libnghttp2=auto, --enable-doh --with-libnghttp2=yes, --disable-doh]
 AC_ARG_ENABLE([doh],