diff --git a/lib/isc/netmgr/netmgr-int.h b/lib/isc/netmgr/netmgr-int.h
index d45734ecc7..c7f721b2a0 100644
--- a/lib/isc/netmgr/netmgr-int.h
+++ b/lib/isc/netmgr/netmgr-int.h
@@ -1321,7 +1321,7 @@ isc__nm_closesocket(uv_os_sock_t sock);
  */
 
 isc_result_t
-isc__nm_socket_reuse(uv_os_sock_t fd);
+isc__nm_socket_reuse(uv_os_sock_t fd, int val);
 /*%<
  * Set the SO_REUSEADDR or SO_REUSEPORT (or equivalent) socket option on the fd
  */
diff --git a/lib/isc/netmgr/socket.c b/lib/isc/netmgr/socket.c
index 7440c0b855..8f02dc848d 100644
--- a/lib/isc/netmgr/socket.c
+++ b/lib/isc/netmgr/socket.c
@@ -159,7 +159,7 @@ isc__nm_closesocket(uv_os_sock_t sock) {
 }
 
 isc_result_t
-isc__nm_socket_reuse(uv_os_sock_t fd) {
+isc__nm_socket_reuse(uv_os_sock_t fd, int val) {
 	/*
 	 * Generally, the SO_REUSEADDR socket option allows reuse of
 	 * local addresses.
@@ -173,12 +173,12 @@ isc__nm_socket_reuse(uv_os_sock_t fd) {
 	 */
 
 #if defined(SO_REUSEPORT) && !defined(__linux__)
-	if (setsockopt_on(fd, SOL_SOCKET, SO_REUSEPORT) == -1) {
+	if (setsockopt(fd, SOL_SOCKET, SO_REUSEPORT, &val, sizeof(val)) == -1) {
 		return (ISC_R_FAILURE);
 	}
 	return (ISC_R_SUCCESS);
 #elif defined(SO_REUSEADDR)
-	if (setsockopt_on(fd, SOL_SOCKET, SO_REUSEADDR) == -1) {
+	if (setsockopt(fd, SOL_SOCKET, SO_REUSEADDR, &val, sizeof(val)) == -1) {
 		return (ISC_R_FAILURE);
 	}
 	return (ISC_R_SUCCESS);
diff --git a/lib/isc/netmgr/tcp.c b/lib/isc/netmgr/tcp.c
index f43b1118b0..1916b79998 100644
--- a/lib/isc/netmgr/tcp.c
+++ b/lib/isc/netmgr/tcp.c
@@ -289,7 +289,7 @@ isc__nm_tcp_lb_socket(isc_nm_t *mgr, sa_family_t sa_family) {
 
 	/* FIXME: set mss */
 
-	result = isc__nm_socket_reuse(sock);
+	result = isc__nm_socket_reuse(sock, 1);
 	RUNTIME_CHECK(result == ISC_R_SUCCESS);
 
 	if (mgr->load_balance_sockets) {
diff --git a/lib/isc/netmgr/udp.c b/lib/isc/netmgr/udp.c
index 82f99a61c8..4da1db8519 100644
--- a/lib/isc/netmgr/udp.c
+++ b/lib/isc/netmgr/udp.c
@@ -78,7 +78,7 @@ isc__nm_udp_lb_socket(isc_nm_t *mgr, sa_family_t sa_family) {
 	(void)isc__nm_socket_disable_pmtud(sock, sa_family);
 	(void)isc__nm_socket_v6only(sock, sa_family);
 
-	result = isc__nm_socket_reuse(sock);
+	result = isc__nm_socket_reuse(sock, 1);
 	RUNTIME_CHECK(result == ISC_R_SUCCESS);
 
 	if (mgr->load_balance_sockets) {
@@ -752,9 +752,10 @@ fail:
 
 static isc_result_t
 udp_connect_direct(isc_nmsocket_t *sock, isc__nm_uvreq_t *req) {
-	int uv_bind_flags = UV_UDP_REUSEADDR;
+	int uv_bind_flags = 0;
 	int r;
 	isc__networker_t *worker = sock->worker;
+	isc_result_t result;
 
 	r = uv_udp_init(&worker->loop->loop, &sock->uv_handle.udp);
 	UV_RUNTIME_CHECK(uv_udp_init, r);
@@ -771,6 +772,12 @@ udp_connect_direct(isc_nmsocket_t *sock, isc__nm_uvreq_t *req) {
 	}
 	isc__nm_incstats(sock, STATID_OPEN);
 
+	/*
+	 * uv_udp_open() enables REUSE_ADDR, we need to disable it again.
+	 */
+	result = isc__nm_socket_reuse(sock->fd, 0);
+	RUNTIME_CHECK(result == ISC_R_SUCCESS);
+
 	if (sock->iface.type.sa.sa_family == AF_INET6) {
 		uv_bind_flags |= UV_UDP_IPV6ONLY;
 	}
@@ -846,9 +853,6 @@ isc_nm_udpconnect(isc_nm_t *mgr, isc_sockaddr_t *local, isc_sockaddr_t *peer,
 	sock->client = true;
 
 	sock->fd = fd;
-	result = isc__nm_socket_reuse(sock->fd);
-	RUNTIME_CHECK(result == ISC_R_SUCCESS ||
-		      result == ISC_R_NOTIMPLEMENTED);
 
 	(void)isc__nm_socket_disable_pmtud(sock->fd, sa_family);
 
diff --git a/tests/isc/doh_test.c b/tests/isc/doh_test.c
index 072816cf24..c8240281f9 100644
--- a/tests/isc/doh_test.c
+++ b/tests/isc/doh_test.c
@@ -247,7 +247,7 @@ setup_ephemeral_port(isc_sockaddr_t *addr, sa_family_t family) {
 		return (r);
 	}
 
-	result = isc__nm_socket_reuse(fd);
+	result = isc__nm_socket_reuse(fd, 1);
 	if (result != ISC_R_SUCCESS && result != ISC_R_NOTIMPLEMENTED) {
 		fprintf(stderr,
 			"setup_ephemeral_port: isc__nm_socket_reuse(): %s",