diff --git a/lib/netdev-dpdk.c b/lib/netdev-dpdk.c
index 2c92bd3f2..bba4de378 100644
--- a/lib/netdev-dpdk.c
+++ b/lib/netdev-dpdk.c
@@ -76,9 +76,10 @@ static struct vlog_rate_limit rl = VLOG_RATE_LIMIT_INIT(5, 20);
 #define MTU_TO_MAX_FRAME_LEN(mtu)   ((mtu) + ETHER_HDR_MAX_LEN)
 #define FRAME_LEN_TO_MTU(frame_len) ((frame_len)                    \
                                      - ETHER_HDR_LEN - ETHER_CRC_LEN)
-#define MBUF_SIZE(mtu)              (MTU_TO_MAX_FRAME_LEN(mtu)      \
-                                     + sizeof(struct dp_packet)     \
-                                     + RTE_PKTMBUF_HEADROOM)
+#define MBUF_SIZE(mtu)              ROUND_UP((MTU_TO_MAX_FRAME_LEN(mtu) \
+                                             + sizeof(struct dp_packet) \
+                                             + RTE_PKTMBUF_HEADROOM),   \
+                                             RTE_CACHE_LINE_SIZE)
 #define NETDEV_DPDK_MBUF_ALIGN      1024
 #define NETDEV_DPDK_MAX_PKT_LEN     9728